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Proven Effective

Clinical studies have proven reSET-O and reSET to be effective in helping improve outcomes in patients with opioid use disorder (OUD) and substance use disorder (SUD).1,2

reSET-O can help people with opioid use disorder stay in recovery.

A study of patient retention rates showed that 82% of X Opioid Use Disorder (OUD) is the misuse of opioids. OUD patients who received treatment with reSET-O stayed in treatment, versus 68% of those who only received treatment as usual (TAU).2*

*A Therapeutic Education System (TES) with equivalent content to reSET-O was studied in this trial as opposed to reSET-O itself.2

TAU = Treatment As Usual

Retention rate by treatment group during the 12-week intervention

Effectiveness - Chart 1 - no background

reSET-O therapeutic content has been validated in a clinical trial.

The efficacy of reSET-O was evaluated in a pivotal, randomized trial of 170 patients seeking treatment for OUD.1

The desktop-based Therapeutic Education System (TES) was validated in a randomized clinical trial through the National Institute on Drug Abuse (NIDA) Clinical Trial Network.1,2

*A Therapeutic Education System (TES) with equivalent content to reSET-O was studied in this trial as opposed to reSET-O itself.2

TAU = Treatment As Usual

1. reSET-O Clinician directions for use. Pear Therapeutics, Inc.; 2019. 2. Christensen DR, Landes RD, Jackson L, et al. Adding an internet-delivered treatment to an efficacious treatment package for opioid dependence. J Consult Clin Psychol. 2014;82(6):964-972. 3. Data on file. reSET-O clinical study report. Document ID# CSR-0001, Rev A. May 2016.

Study Design3*

Effectiveness - Pop up 1

reSET more than doubled abstinence rates when added to outpatient therapy.*

A clinical study showed that patients in recovery from X Substance Use Disorder (SUD) is caused by the repeated use of alcohol and/or drugs. substance use disorder , whose primary substance of abuse was not opioids, were more than 2X likely to abstain from drug use when reSET was added to X Outpatient therapy is when a patient visits a medical facility for diagnosis or treatment without staying overnight. outpatient therapy versus when it was not.1,

*As determined in the last 4 weeks of therapy. Abstinence was not measured until weeks 9 to 12 of the study.
†A Therapeutic Education System (TES) with equivalent content to reSET was studied in this trial as opposed to reSET itself.1

TAU= Treatment As Usual
rTAU = Reduced Treatment As Usual
OR = Odds Ratio
CI = Confidence Interval

Abstinence rate (%) by treatment group, weeks 9-12

Effectiveness - Chart 2 - no background

reSET Study Design1,2*

ALL-COMERS (n=507):

Patients with SUD were initially screened and randomized to 12 weeks of outpatient therapy:

  • Treatment as usual (TAU), or
  • reSET + reduced TAU (rTAU) (2 hours reduced face-to-face therapy)

EXCLUDING PRIMARY OPIOIDS (n=399):

All-comers excluding those whose primary substance of abuse was opioids.

NON-ABSTINENT AT STUDY START (n=192):

All-comers excluding those whose primary substance of abuse was opioids. Subset of patients who were non-abstinent at study start.

The primary outcome measures of the pivotal study were abstinence from drug and alcohol use and treatment retention. Abstinence was measured twice a week (i.e., for each half-week) by Urine Drug Screen (UDS), Breathalyzer, and Time-Line-Follow-Back (TLFB) self-report of substance abuse. Treatment retention was assessed by the date of the patient’s last face-to-face contact with the clinician/therapist.

*reSET is indicated as a 12-week (90 day) prescription-only treatment for patients with SUD, who are not currently on opioid replacement therapy, who do not abuse alcohol solely, or who do not abuse opioids as their primary substance of abuse.

A Therapeutic Education System (TES) with equivalent content to reSET was studied in this trial as opposed to reSET itself.1.3

References: 1. reSET Clinician directions for use. Pear Therapeutics, Inc; 2019. 2. Data on file. reSET clinical study report. Document ID# CSR-0001, Rev A. November 28, 2017. 3. Campbell ANC, Nunes EV, Matthews AG, et al. Internet-delivered treatment for substance abuse: a multisite randomized controlled trial. Am J Psychiatry. 2014;171(6):683-690.

Study Design1,2*†

Effectiveness - Pop up 2

reSET improved treatment retention when added to outpatient therapy.

For all patients, adding reSET to X Outpatient therapy is when a patient visits a medical facility for diagnosis or treatment without staying overnight. outpatient therapy improved retention rates.1,3*

*A Therapeutic Education System (TES) with equivalent content to reSET was studied in this trial as opposed to reSET itself.1

TAU = Treatment As Usual
rTAU = Reduced Treatment As Usual
HR = Hazard Ratio
CI = Confidence Interval

Retention rate by treatment group during the 12-week intervention.

Effectiveness - Chart 3 - no background

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References: 1. reSET Clinician directions for use. Pear Therapeutics, Inc; 2019. 2. reSET-O Clinician directions for use. Pear Therapeutics, Inc.; 2019. 3. reSET clinical study report. Document ID# CSR-0001, Rev A. Data on file. November 28, 2017.